The Columbia Center for Human Development (CCHD)

Columbia Center for Human Development Seminar Series

Location – CCHD Conference Room, William Black Building, 8th Floor, Room 814



Date	Speaker	Title


7/12/23	Zhiyu Dai, PhD Assistant Professor, Director Translational Endothelial Research, Dept. of Internal Medicine, University of Arizona College of Medicine	Endothelial Dysfunction in the Pathogenesis of Pulmonary Arterial Hypertension

6/09/23	Ralf Jauch, PhD Associate Professor Center Translational Stem Cell Research, Hong Kong University	Inducing next generation stem cell models with engineered SOX17

5/22/23	Saverio Bellusci, PhD Professor Department of Internal Medicine Justus-Liebig University, Giessen, Germany	Harnessing fibroblast growth factor 10’s power in lung repair: impact on alveolar epithelial stem cells (and their mesen-chymal niches)

05/19/23	Jun Wu, PhD Assistant Professor Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX	Dynamic Pluripotent Stem Cells and Their Applications

04/28/23	Shuibing Chen, PhD Kilts Family Professor of Surgery & Professor of Biochemistry Weill Medical Medicine Cornell University	Huma Pluripotent Stem Cells, Organoid, and Disease Modeling

01/11/23	Xiaobo Zhou, PhD Functional Genomics Laboratory Brigham & Women’s Hospital Harvard Medical School	Genetic susceptibility to COPD caused by failed alveolar repair

12/15/22	Joo-Hyeon Lee, PhD Wellcome-MRC Cambridge Stem Cell Institute University of Cambridge, UK	Reprogramming of stem cells and niches in lung regeneration and disease

11/16/22	Nanolive Platform Presentation	CCHD Technology Seminar -Live Cell Imaging & Analysis

10/20/22	C. Filipe R. L. Pereira, PhD Department of Molecular Medicine & Gene Therapy Lund Stem Cell Center Lund University Sweden	Cell Fate Reprogramming in Hematopoiesis & Immunity

05/11/22	Rossana Calderon Moreno, PhD Department of Preventive Medicine, Columbia University	Fantastic retinoids and where to find them: The secrets of the intestinal epithelium

04/13/22	Jaime Rubin, PhD Professor of Medical Sciences, Vice-Chair for Investigator Development, Columbia University	Funding and Grantsmanship

02/23/22	Takanori Takebe, MD Associate Professor of Pediatrics Center of Stem Cell & Organoid Medicine Cincinnati Children’s Hospital Medical Center	Hepato-Biliary-Pancreatic Organogenesis in a Dish

12/08/21	Maria Caterina De Rosa, PhD Dept. Pediatrics Molecular Genetics, Columbia University Bindu C. Sundaresan, PhD Advanced Cell Diagnostics	CCHD Technology Seminar - Spatial profiling of a diverse range of RNA targets at the single cell level

11/10/21	Jun Wu, PhD Assistant Professor, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX	Dynamic Pluripotent Stem Cells and Their Applications

10/02/21	Xin Sun, PhD Professor, Department of Pediatrics, Cell and Developmental Biology, University of California, San Diego School of Medicine	From Single Cell Profiles to Lung Health: Learning Basic Biology from Pediatric Diseases

04/14/21	Emma L. Rawlins, PhD Senior Group Leader, Gurdon Institute, Dept. of Physiology, Development & Neuroscience, University of Cambridge	Building the human lung: lessons from organoids

03/31/21	Tushar Desai, MD Associate Professor of Medicine, Dept. of Internal Medicine, Division of Pulmonary & Critical Care Medicine Stanford Medicine	Making headway towards a cell therapy for cystic fibrosis

03/10/21	Michael Laflamme, MD, PhD Senior Scientist, McEwen Stem Cell Institute, Robert McEwen Chair in Cardiac Regenerative Medicine University Health Network, University of Toronto	Heart Regeneration with Pluirpotent Stem Cells

12/16/20	Maria-Elena Torres-Padilla, PhD Professor Ludwig Maximilians University, Munich; Director, Institute of Epigenetics & Stem Cell Helmholtz Centre, Munich	Epigenetic mechanisms in early mammalian development

11/04/20	Jayaraj Rajagopal, MD Professor of Medicine, Dept. of Medicine, Harvard Medical School, Massachusetts General Hospital; Center for Regenerative Medicine	Novel Injury Responses in the airway epithelium

06/02/20	Carla Kim, PhD Professor, Children’s Hospital Boston, Stem Cell Program, Dept. of Genetics, Harvard Medical School, Harvard Stem Cell Institute	Regulation of Lung Progenitors and their microenvironment
	COVID-19 Symposiums Andrea Califano, PhD Professor of Chemical Biology (in Systems Biology) & Biomedical Informatics & Biochemistry & Molecular Biophysics & Medicine in Inst. Of Cancer Genetics	Weekly Seminar Series covering COVID-19 Research at CUIMC as well as Nationally & Internationally

01/30/20	Jinsong Li, PhD Professor and Director State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences	“Artificial spermatid” – mediated genome editing

12/12/19	Matthias C. Kugler, MD Assistant Professor of Medicine Pulmonary & Critical Care Medicine New York University School of Medicine New York University Langone Health	Hedgehog signaling – directions to mesenchyme during postnatal lung growth

12/10/19	Anthony Oro, MD, PhD Professor of Dermatology, Institute for Stem Cell Biology & Regenerative Medicine, Children’s Health Research Institute, Stanford University	DNA Origami and the Chromatin Dynamic Regulation of Epithelial Commitment

12/05/19	Da-Zhi Wang, PhD Professor of Pediatrics, Harvard Medical School Dept. of Cardiology, Boston Children’s Hospital	Molecular regulation of Cardiovascular Function & Disease

11/14/19	Michelle Tallquist, PhD Associate Professor Center for Cardiovascular Research John A. Burns School of Medicine University of Hawaii	Fibroblast Roles in Cardiac and Pulmonary Development and Disease

11/07/19	Hongxu Ding, PhD Postdoctoral Scholar, Genomics Institute, UC Santa Cruz, Adjunct Research Scientist, Dept. System Biology, Columbia University	Interpreting scRNA-Seq Data Using Enrichment Analysis

10/31/19	Andrew E. Vaughan, PhD Assistant Professor Biomedical Sciences & Institute for Regenerative Medicine University of Pennsylvania School of Medicine	Rare cells, big effects: Small cell populations in lung regeneration

10/10/19	Hee Won Yang, PhD Assistant Professor of Pathology & Cell Biology Department of Pathology & Cell Biology Columbia University Irving Medical Center	Regulation of cell-cycle entry

09/19/19	Jianlong Wang, PhD Professor of Medicine Columbia Center for Human Development Division of Pulmonary, Allergy & Critical Care Medicine Columbia University Irving Medical Center	Genetic & Epigenetic Control of Stem Cell & Developmental Potency

08/16/19	Vincent Luca, PhD Assistant Member Moffitt Cancer Center & Research Institute, Departments of Drug Discovery & Malignant Hematology Assistant Professor, Morsani College of Medicine University South Florida School of Medicine	Illuminating Notch and Wnt signaling mechanisms through protein engineering

07/19/19	Shimpei Gotoh, MD, PhD Associate Professor Department of Respiratory Medicine & Department of Drug Discovery for Lung Diseases Graduate School of Medicine Kyoto University	Derivation of functional alveolar & airway cells & their applica-tions to disease modeling

06/21/19	Xiao Zhao, MD Instructor of Medicine Division of Gastroenterology University of Pennsylvania Perelman School of Medicine	Mechanistic & Therapeutic Insights into Biliary Atresia- A model to understand cholangiocytes under stress

04/11/19	Columbia Center for Human Development & Dept. of Genetics & Development Combined Seminar Mark Krasnow, PhD, MD Paul and Mildred Berg Professor Chair, Department of Biochemistry Stanford University School of Medicine	Lung stem cells, their niches and cancer at single cell resolution

03/25/19	Michele Battle, PhD Associate Professor, Dept. Cell Biology, Neurobiology & Anatomy, University of Wisconsin	GATA4 and development of the squamocolumnar junction: Implications for Barrett’s esophagus

03/20/19	pJames Wells, PhD Professor, Division of Developmental Biology Director for Basic Research, Div. of Endocrinology Chief Scientific Officer, Center for Stem Cell & Organoid Medicine, Cincinnati Children’s Hospital	Human pluripotent stem cell-derived GI organoid models to study development and disease

02/14/19	Chao Lu, PhD Assistant Professor of Genetics & Development Department of Genetics & Development Columbia University Irving Medical Center	Chromatin Regulation in Tissue Homeostasis and Tumorigenesis

01/24/19	Christine Garcia, MD, PhD Professor of Medicine, Dept. of Medicine (Pulmonary Division)	Genetics of Pulmonary Fibrosis: Creating Mouse Models of Disease Based on Human Rare Variant Discoveries

04/19/18	Hiromitsu Nakauchi, MD, PhD Columbia Center for Human Development & Columbia Stem Cell Initiative Combined Seminar Professor, Institute for Stem Cell Biology & Regenerative Medicine, Stanford University	Interspecies blastocyst complementation for generation of functional organs

03/29/18	Juan Carlos Izpisua Belmonte, PhD Professor of Gene Expression Laboratory Roger Guillemin Chair Salk Institute for Biological Sciences	Repairing the human body: genetic and epigenetic approaches

02/22/18	Christine (Iok In) Chio, PhD Assistant Professor of Genetics & Development Institute of Cancer Genetics Department of Genetics & Development Columbia University	Targeting redox dependencies in pancreatic cancer

01/18/18	Guang Li, PhD Postdoctoral Fellow Cardiovascular Institute Stanford University School of Medicine	Study of heart development at the single-cell level

01/11/18	Mingxia Gu, PhD Instructor, Pediatrics Cardiology Stanford University School of Medicine	Using Patient-Specific iPSCs to Understand & Treat Pulmonary Arterial Hypertension

12/07/17	Jingli Cao, PhD Postdoctoral Fellow Department of Cell Biology Duke University School of Medicine	Uncovering Mechanisms of Natural Heart Regeneration in Zebrafish

12/06/17	David Warburton, OBE, DSc, MD Professor of Pediatrics Director, Developmental Biology & Regenerative Medicine, Keck School of Medicine University of Southern California	On the development, form & function of the gas diffusion surfaces in the mouse and human lung

10/21/17	Jin-Ah Park, PhD Assistant Professor of Airway Biology Molecular & Integrative Physiological Sciences Department of Environmental Health Harvard T.H. Chan School of Public Health	Unjamming transition of the airway epithelium and its implication in asthma

09/28/17	Vincent Yang, MD, PhD Chair of Medicine and Professor Departments of Medicine & Physiology and Biophysics Stony Brook University Medicine	Intestinal Stem Cells: Dynamics and Regulation

08/18/17	Nan Tang, MD, PhD Assistant Investigator National Institute of Biological Sciences Beijing, China	The driving force of alveolar development and regeneration

05/18/17	Lin He, PhD Associate Professor of Molecular and Cell Biology Department of Molecular and Cell Biology University of California, Berkeley	miRNAs, small yet mighty gene regulators of development and disease

04/13/17	Catherine Pei-Ju Lu, PhD Research Associate Laboratory of Mammalian Cell Biology & Development Rockefeller University New York, NY	How do skin progenitors decide to grow hair or sweat glands? From the discovery of sweat gland stem cells to future skin regeneration.

03/23/17	Yen-Sin Ang, PhD Postdoctoral Fellow Gladstone Institute of Cardiovascular Disease University of California San Francisco	Gene regulatory mechanisms in human cardiogenesis

02/23/17	Stephanie Protze, PhD Postdoctoral Fellow McEwen Centre for Regenerative Medicine University Health Network Toronto	Translating human heart development to novel biological pacemaker therapies using pluripotent stem cells

01/18/17	Tushar J. Desai, MD Assistant Professor of Medicine Department of Internal Medicine Division of Pulmonary & Critical Care Medicine Stanford University	A Niche-Centric View of Lung Renewal and Repair by Alveolar Type 2 Stem Cells

10/20/16	Thomas Mariani, PhD Professor, Department of Pediatrics, Neonatology & Department of Environmental Science University of Rochester Medical Center	Molecular characterization of the human infant airway

10/06/16	Loredana Quadro, PhD Associate Professor, Rutgers University, Dept. of Food Science, School of Environmental & Biological Sciences	Regulation of lipoprotein biosynthesis by carotenoids to optimize maternal-fetal transfer of beta-carotene

08/25 /16	Danwei Huangfu, PhD Asst. Member, Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center Asst. Professor, Cell & Developmental Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY	Human development through the lens of pluripotent stem cells

07/28/16	Wendy Chung, MD, PhD Kennedy Family Associate Professor of Pediatrics & Medicine, Director, Clinical Genetics Program CUMC, Co-Director, Precision Medicine Resources Irving Institute for Clinical & Translational Medicine, Co-Director, Molecular Genetics Diagnostic Laboratory	The genomic basis for congenital heart disease

06/23/16	Matthias Stadtfeld, PhD Assistant Professor, Skirball Institute of Biomolecular Medicine, Developmental Genetics, Department of Cell Biology, New York University School of Medicine	Shortcuts to induced pluripotency and the acquisition of developmental potency during iPSC formation

06/09/16	Richard Valle, PhD Professor of Pathology and Cell Biology, Director, Division of Cell & Molecular Biology, Columbia Motor Neuron Center, Columbia University Medical Center	Microtubules, Motors, and Microcephaly

05/17/16	Jun Sun, PhD Associate Professor, Division of Gastroenterology & Hepatology, Department of Medicine, University of Illinois at Chicago	Explore vitamin D/vitamin D receptor and microbiota in inflammation and cancer

05/05/16	Xin Zhang, PhD Jules & Doris Stein RPB Associate Professor, Department of Ophthalmology, Pathology & Cell Biology, Columbia University Medical Center	Proteoglycan regulation of astrocyte migration and angiogenesis

03/24/16	Kelly Yan, MD, PhD Instructor of Medicine, Department of Medicine, Stanford University, Stanford, California	Non-equivalence of extracellular Wnt and R-spondin ligands in intestinal stem cell self-renewal

03/16/16	Jichao Chen, PhD Assistant Professor, Department Pulmonary Medicine & Biochemistry & Molecular Biology, University of Texas MD Anderson Cancer Center	What an ultrathin cell can do: structural & signaling roles of the lung alveolar type 1 cell

03/03/16	Kathryn Anderson, PhD Chair, Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center	Primary Cilia and Hedgehog Signaling

02/18/16	Renat Shaykhiev, MD, PhD Assistant Professor of Medicine Weill Cornell Medical College, New York, NY	Reprogramming of Airway Stem Cell Fate in Lung Disease

02/16/16	Kate Ackerman, MD Associate Professor of Pediatrics, Critical Care and Biomedical Genetics, University of Rochester Medical Center School of Medicine & Dentistry	Genetic Mouse Models of Human Birth Defects: Identification of the mesothelium as a contributor to the diaphragm

01/28/16	Hideo Watanabe, MD, PhD Assistant Professor of Medicine, Pulmonary, Critical Care & Sleep Medicine and Genetics & Genomic Sciences, Icahn School of Medicine, Mt. Sinai Hospital, New York, NY	Transcriptional Regulators of Cell Lineages in Lung Cancer

12/03/15	Bernard Thebaud, MD, PhD Professor of Pediatrics University of Ottawa Chair, Ottawa Partnership Research in Regenerative Medicine, Ottawa Hospital Research Institute Neonatologist, Children’s Hospital of Eastern Ontario Research Institute Ottawa, Canada	No vessels, no lung: endothelial progenitor cells for chronic lung disease of prematurity

11/12/15	Xin Sun, PhD Professor of Medical Genetics Laboratory of Genetics University of Wisconsin-Madison Madison, WI	Building a Functional Lung: Lessons from Genetic Mouse Models

11/05/15	Piero Dalerba, MD Assistant Professor of Pathology & Cell Biology Department of Pathology & Cell Biology Columbia University Medical Center	Using “single-cell genomics” to dissect the cell composition of human tissues

10/15/15	Danelle Devenport, PhD Assistant Professor of Molecular Biology Department of Molecular Biology Princeton University Princeton, NJ	Establishing long-range tissue polarity in the mammalian epidermis

09/08/15	Kiyotaka Sasagawa, PhD Assistant Professor Photonic Device Science Laboratory Nara Institute of Science & Technology Nara, Japan	Implantable image sensors for brain imaging

08/14/15	Jose Xavier Neto, MD, PhD Director, Genome Modification Laboratory National Biosciences Laboratory Sao Paulo, Brazil	Emergence of vertebrate cardiac chambers as evolutionary novelties: of waves and fossil hearts

07/09/15	Elaine Fuchs, PhD Rebecca C. Lancefield Professor Robin Chemers Neustein Laboratory of Mammalian Cell Biology & Development The Rockefeller University, New York, New York	Stem cells in silence, action and cancer

06/25/15	Patricia Dahia, MD, PhD Associate Professor Cancer Research and Therapy Center –Dept. Medicine University of Texas Health Science Center San Antonio San Antonio, TX	Genetics of chromatin cell transformation

04/23/15	Catherine Pei-Ju Lu, PhD Postdoctoral Research Fellow Laboratory of Mammalian Cell Biology & Development Rockefeller University New York, NY	Stem cells in the sweat glands: development, wound repair and regeneration

03/05/15	Hisham Bazzi, PhD Research Fellow Sloan Kettering Institute Developmental Biology Program Memorial Sloan Kettering Cancer Center New York, NY	The roles of centrosomes in mice

02/05/15	Valerie Gouon-Evans, PhD Assistant Professor Mt. Sinai School of Medicine Black Family Stem Cell Institute-Tisch Cancer Institute New York, NY	Pluripotent Stem Cell Derived- Hepatocytes: From Developmental Discoveries to Clinical Applications

01/29/15	Saverio Bellusci, PhD Professor, ECCPS University Justus Liebig Giessen, Germany	Mesenchymal lineage formation during lung development and disease; role of the FGF pathway