CCHD – CSCT ANNOUNCEMENTS January 2024
AWARDS & PUBLICATIONS

Awards and Honors - Congratulations

Dr. Jianlong Wang received an R01 from the Institute of Child Health & Human Development this January for “A Nucleolar Paradigm for Pluripotency of Human Embryonic Stem Cells.”

Dr. Jianwen Que most recently received the American Gastroenterological Association’s Funderburg Research Award in Gastric Cancer for “The Role of Intestinal Metaplasia in Gastric Cancer Development.”

Dr. Zurab Ninish, Senior Research Technician (Mori Lab) received the 2023 Clerical Technical Award, Martha A. Hooven Award for Excellence on January 23, 2024 at the Roy and Diana Vagelos Education Center.

PUBLICATIONS

Xin Huang and Research Team
ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J. Dev Cell. 2024 Jan 16:S1534-5807(23)00698-6. doi: 10.1016/j.devcel.2023.12.018. Online ahead of print. PMID: 38237590

John W. Murray
Dynamic regulation of hepatic lipid metabolism by torsinA and its activators.
Hernandez-Ono A, Zhao YP, Murray JW, Östlund C, Lee MJ, Shi A, Dauer WT, Worman HJ, Ginsberg HN, Shin JY.JCI Insight. 2024 Jan 9:e175328. doi: 10.1172/jci.insight.175328. Online ahead of print. PMID: 38194265

Jianwen Que and Research Team
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation.
Bankoti K, Wang W, Amonkar GM, Xiong L, Shui JE, Zhao C, Van E, Mwase C, Park JA, Mou H, Fang Y, Que J, Bai Y, Lerou PH, Ai X. Am J Respir Cell Mol Biol. 2024 Jan;70(1):26-38. doi: 10.1165/rcmb.2023-0104OC. PMID: 37699145

Jianlong Wang and Research Team
ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J. Dev Cell. 2024 Jan 16:S1534-5807(23)00698-6. doi: 10.1016/j.devcel.2023.12.018. Online ahead of print. PMID: 3823759

CCHD – CSCT ANNOUNCEMENTS for January – December 2023
AWARDS & PUBLICATIONS

Awards and Honors - Congratulations

The Wang lab attended the ISSCR 2023 annual meeting during June in Boston, MA. Lab members were selected to present their posters/abstracts:
Former member Dr. Dan Li presented “An RNAI Screen of RNA Helicases Identifies EIF4A3 as a Regulator of Embryonic Stem Cell Identity,” (CCHD-CSCT contributors - Vikas Malik, Xin Huang, Hongwei Zhou, Jianlong Wang).

Dr. Jianlong Wang presented “The Pluripotency Factor TEX10 Finetunes WNT Signaling for PGC and Male Germline Development,” (CCHD-CSCT contributors -Xin Huang, Vikas Malik, Hongwei Zhou).

Dr. Xin Huang presented “ZFP281 Coordinates De Novo DNA Methyltransferases and TET1 in Driving Primed Pluripotency,” (CCHD-CSCT contributors – Vikas Malik, Jianlong Wang).

Dr. Hongwei Zhou presented “DDX18 Coordinates Nucleolus Phase Separation and Chromatin Organization to Control the Pluripotency of Human Embryonic Stem Cells,” (CCHD-CSCT contributors – Xin Huang, Vikas Malik).

Dr. Vikas Malik presented “Investigating the Restorative Functions of Sleep in Neural Stem Cells and Regeneration,” (CCHD-CSCT contributors – Hongwei Zhou, Jianlong Wang).

Dr. Christine Moon (Yan Lab) received a HICCC TAM Postdoctoral Pilot award in July for “Investigating Tumor-reactive Stem-like CD8+ T cells by Organoid Modeling of the Human Colorectal Cancer Microenvironment.”

Dr. Hans-Willem Snoeck in collaboration with Dr. Jellert Gaublomme (Biological Sciences) received the Interdisciplinary Research Initiatives Seed (IRIS) Fund Program award in July for their project involving lung organoid generation, analysis and CRISPR screening.

Dr. Hans-Willem Snoeck also in July, was awarded the Edward P. Evans Center (HICCC) award for Myelodysplastic Syndromes for his project “Nucleolar dysfunction as a therapeutic liability in cohesion mutant MDS.”

Dr. Hans-Willem Snoeck together with Dr. N. Valerio Dorrello (Pediatric Critical Care) received the TRx/ACT (Irving Institute for Clinical Translational Research) for “Cell therapy for alveolar lung diseases” in August.

Brooke Dirvin (Cardoso Lab) was selected to present her poster/abstract “Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium” in August at the Gordon Research Conference on Lung Development, Injury and Repair in Waterville Valley, NH.

Xiangyi (Sherry) Ke (Cardoso Lab) was selected to present her poster/abstract “Morphogenesis and regeneration share a core transition state program that balances proximal-distal lung specification” in August at the Gordon Research Conference on Lung Development, Injury and Repair in Waterville Valley, NH. Sherry received the poster presentation award and an honorarium for her abstract from the Progenitor Cell Translational Consortium (PCTC).

Dr.Takehiro Otoshi (Cardoso Lab) was selected to present his poster/abstract “Impact of genetic background variability in airway hyperresponsiveness by prenatal disruption of retinoic acid signaling” in August at the Gordon Research Conference on Lung Development, Injury and Repair in Waterville Valley, NH.

Dr. Akihiro Miura (Mori Lab) was selected to present his poster/abstract “Exploring the Production of Whole Huma Lungs via Conditional Blastocyst Complementation” in August at the Gordon Research Conference on Lung Development, Injury and Repair in Waterville Valley, NH.

Dr. Akihiro Miura and Dr. Yuko Shimamura (Mori Lab) were honored in October with Overseas Research Fellowships by the Japan Society for the Promotion of Science (JSPS). The two-year awards are the most competitive fellowships in Japan.

Dr. Jonathan Miller (Yan Lab) was selected to present his poster/abstract, “Upper Crypt Progenitor Cells in the Regenerative Response in Rotavirus-Induced Acute Gastroenteritis” in November at the annual NIDDK DDRCC Director’s Meeting in Cincinnati, OH.

Dr. Shang-Hsin (Jason) Wu (Zhao Lab) was selected to present his poster/abstract, “Time-Course RNAseq Revealed Dynamic Transcriptional Changes in a Mouse Model of Toxin-induced Biliary Atresia” in November for the annual American Association for the Study of Liver Diseases (AASLD) in Boston, MA. (CCHD-CSCT contributors – Abigail Spingarn, Xiao Zhao).


PUBLICATIONS

Wellington V. Cardoso and Research Team
Sox9 is associated with two distinct patterning events during snake lung morphogenesis.
van Soldt BJ, Metscher BD, Richardson MK, Cardoso WV. Dev Biol. 2024 Feb;506:7-19. doi: 10.1016/j.ydbio.2023.11.006. Epub 2023 Nov 22. PMID: 37995917

Unravelling the expanding role of FGF10 signalling in lung homeostasis and maintenance.
Neptune ER, Cardoso WV. Eur Respir J. 2023 Nov 9;62(5):2301691. doi: 10.1183/13993003.01691-2023. Print 2023 Nov. PMID: 37945046 

Munemasa Mori and Research Team
Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung.
Miura A, Sarmah H, Tanaka J, Hwang Y, Sawada A, Shimamura Y, Otoshi T, Kondo Y, Fang Y, Shimizu D, Ninish Z, Suer JL, Dubois NC, Davis J, Toyooka S, Wu J, Que J, Hawkins FJ, Lin CS, Mori M. Elife. 2023 Oct 20;12:e86105. doi: 10.7554/eLife.86105. PMID: 37861292 

An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo.
Tsuji M, Nair MS, Masuda K, Castagna C, Chong Z, Darling TL, Seehra K, Hwang Y, Ribeiro ÁL, Ferreira GM, Corredor L, Coelho-Dos-Reis JGA, Tsuji Y, Mori M, Boon ACM, Diamond MS, Huang Y, Ho DD. Nat Commun. 2023 Jul 5;14(1):3959. doi: 10.1038/s41467-023-39738-1. PMID: 37402814

John W. Murray
Engraftment and injury repair in regionally conditioned rat lung in vivo by lung progenitors derived from human pluripotent stem cells.
Liu HY, Predella C, Chen YW, Wang J, Pezet M, Liang S, Farè S, Murray JW, Saqi A, Vunjak-Novakovic G, Snoeck HW, Dorrello NV. bioRxiv. 2023 Nov 29:2023.11.28.569060. doi: 10.1101/2023.11.28.569060. Preprint. PMID: 38077087

Human pluripotent stem cell-derived respiratory airway progenitors generate alveolar epithelial cells and recapitulate features of idiopathic pulmonary fibrosis.
Pezet MG, Torres JA, Thimraj TA, Matkovic Leko I, Schrode N, Murray JW, Beaumont K, Snoeck HW. bioRxiv. 2023 Oct 31:2023.01.30.526265. doi: 10.1101/2023.01.30.526265. Preprint. PMID: 36778291 

Interaction of Human OATP1B1 with PDZK1 Is Required for Its Trafficking to the Hepatocyte Plasma Membrane.
Wang P, Murray JW, Wolkoff AW. Drug Metab Dispos. 2023 Oct;51(10):1342-1349. doi: 10.1124/dmd.123.001248. Epub 2023 Jul 13. PMID: 37442606

Jianwen Que and Research Team
Adapting Nanopore Sequencing Basecalling Models for Modification Detection via Incremental Learning and Anomaly Detection.
Wang Z, Fang Y, Liu Z, Hao N, Zhang HH, Sun X, Que J, Ding H. bioRxiv. 2023 Dec 20:2023.12.19.572449. doi: 10.1101/2023.12.19.572449. Preprint. PMID: 38187611

Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma.
Lu H, Cao LL, Ballout F, Belkhiri A, Peng D, Chen L, Chen Z, Soutto M, Wang TC, Que J, Giordano S, Washington MK, Chen S, McDonald OG, Zaika A, El-Rifai W. Gut. 2023 Dec 7;73(1):47-62. doi: 10.1136/gutjnl-2023-329455. PMID: 37734913

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma.
Chen Y, Zhang K, Zhang R, Wang Z, Yang L, Zhao T, Zhang S, Lin Y, Zhao H, Liu Y, Wei Y, Zhou Y, Zhang J, Ye X, Zhao J, Li X, Que J, Shi S, Liu K. Cell Death Discov. 2023 Oct 27;9(1):399. doi: 10.1038/s41420-023-01693-7. PMID: 37891174 

Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung.
Miura A, Sarmah H, Tanaka J, Hwang Y, Sawada A, Shimamura Y, Otoshi T, Kondo Y, Fang Y, Shimizu D, Ninish Z, Suer JL, Dubois NC, Davis J, Toyooka S, Wu J, Que J, Hawkins FJ, Lin CS, Mori M. Elife. 2023 Oct 20;12:e86105. doi: 10.7554/eLife.86105. PMID: 37861292

m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner.
Zhang Y, Zhang W, Zhao J, Ito T, Jin J, Aparicio AO, Zhou J, Guichard V, Fang Y, Que J, Urban JF Jr, Hanna JH, Ghosh S, Wu X, Ding L, Basu U, Huang Y. Nat Immunol. 2023 Aug;24(8):1256-1264. doi: 10.1038/s41590-023-01548-4. Epub 2023 Jul 3. PMID: 37400674

Hans-Willem Snoeck and Research Team
Engraftment and injury repair in regionally conditioned rat lung in vivo by lung progenitors derived from human pluripotent stem cells.
Liu HY, Predella C, Chen YW, Wang J, Pezet M, Liang S, Farè S, Murray JW, Saqi A, Vunjak-Novakovic G, Snoeck HW, Dorrello NV. bioRxiv. 2023 Nov 29:2023.11.28.569060. doi: 10.1101/2023.11.28.569060. Preprint. PMID: 38077087

Human pluripotent stem cell-derived respiratory airway progenitors generate alveolar epithelial cells and recapitulate features of idiopathic pulmonary fibrosis.
Pezet MG, Torres JA, Thimraj TA, Matkovic Leko I, Schrode N, Murray JW, Beaumont K, Snoeck HW. bioRxiv. 2023 Oct 31:2023.01.30.526265. doi: 10.1101/2023.01.30.526265. Preprint. PMID: 36778291 

Jianlong Wang and Research Team
Mild sleep restriction increases endothelial oxidative stress in female persons.
Shah R, Shah VK, Emin M, Gao S, Sampogna RV, Aggarwal B, Chang A, St-Onge MP, Malik V, Wang J, Wei Y, Jelic S. Sci Rep. 2023 Sep 16;13(1):15360. doi: 10.1038/s41598-023-42758-y. PMID: 37717072 

An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission.
Daniel JA, Elizarova S, Shaib AH, Chouaib AA, Magnussen HM, Wang J, Brose N, Rhee J, Tirard M. Front Mol Neurosci. 2023 Jul 14;16:1115880. doi: 10.3389/fnmol.2023.1115880. eCollection 2023. PMID: 37533751

Kelley Yan and Research Team
Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration.
Jiang Z, Waterbury QT, Malagola E, Fu N, Kim W, Ochiai Y, Wu F, Guha C, Shawber CJ, Yan KS, Wang TC. Cell Mol Gastroenterol Hepatol. 2023 Oct 28;17(3):321-346. doi: 10.1016/j.jcmgh.2023.10.007. Online ahead of print. PMID: 37898454

Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease.

Kornberg A, Botella T, Moon CS, Rao S, Gelbs J, Cheng L, Miller J, Bacarella AM, García-Vilas JA, Vargas J, Yu X, Krupska I, Bush E, Garcia-Carrasquillo R, Lebwohl B, Krishnareddy S, Lewis S, Green PHR, Bhagat G, Yan KS, Han A. Sci Immunol. 2023 Jul 21; 8(85):eadf4312. doi: 10.1126/sciimmunol.adf4312. Epub 2023 Jul 14. PMID: 37450575

CCHD – CSCT ANNOUNCEMENTS for Summer – Autumn 2022
AWARDS & PUBLICATIONS

Cardoso Lab
Awards
Dr. Takehiro Otoshi Received the Noa Noy Memorial Fund Award to attend the FASEB 6th International Conference on Retinoids June 5-10, 2022, Athens, Ohio for his presentation “Impact of genetic background variability in airway hyperresponsiveness by prenatal disruption of retinoic acid signaling.”

Dr. Yizhuo Zhou also received a travel award from the FASEB 6th International Conference on Retinoids for her presentation “A distinct population of airway basal cell activates an aberrant metaplastic program of differentiation under retinoid deficiency.”

Publications
Airway basal cells show regionally-distinct potential to undergo metaplastic differentiation.
Zhou Y, Yang Y, Guo L, Qian J, Ge J, Sinner D, Ding H, Califano A, Cardoso WV. Elife. 2022 Sep 30;11:e80083. doi: 10.7554/eLife.80083. Online ahead of print. PMID: 36178196

Contribution of Trp63CreERT2 labeled cells to alveolar regeneration is independent of tuft cells.
Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J.Elife. 2022 Sep 21;11:e78217. doi: 10.7554/eLife.78217. Online ahead of print. PMID: 36129169

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.
Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV. iScience. 2022 Jul 14;25(8):104751. doi: 10.1016/j.isci.2022.104751. eCollection 2022 Aug 19. PMID: 3594210

Intravitreal Bevacizumab Is Associated with Prolonged Ventilatory Support in Preterm Infants with Bronchopulmonary Dysplasia.
Huang CY, Huang HC, Chen MH, Lai TT, Chou HC, Chen CY, Yen TA, Cardoso WV, Tsao PN.Chest. 2022 Jun 23:S0012-3692(22)01183-7. doi: 10.1016/j.chest.2022.06.017. Online ahead of print. PMID: 35753385

Mori Lab
Awards
Dr. Akihiro Miura is the recipient of the Uehara Memorial Foundation Research Fellowship award, Japan for 2023.

Publications
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication. Tanaka J, Senpuku H, Ogawa M, Yasuhara R, Ohnuma S, Takamatsu K, Watanabe T, Mabuchi Y, Nakamura S, Ishida S, Sadaoka T, Takaki T, Shirota T, Shimane T, Inoue T, Sakai T, Mori M, Tsuji T, Saito I, Mishima K.Nat Cell Biol. 2022 Nov;24(11):1595-1605. doi: 10.1038/s41556-022-01007-6. Epub 2022 Oct 17.PMID: 36253535

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.
Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV. iScience. 2022 Jul 14;25(8):104751. doi: 10.1016/j.isci.2022.104751. eCollection 2022 Aug 19. PMID: 3594210

Injectable hyaluronic acid hydrogel encapsulated with Si-based NiO nanoflower by visible light cross-linking: Its antibacterial applications. Gwon K, Park JD, Lee S, Choi WI, Hwang Y, Mori M, Yu JS, Lee DN.Int J Biol Macromol. 2022 May 31;208:149-158. doi: 10.1016/j.ijbiomac.2022.03.051. Epub 2022 Mar 16. PMID: 35304194

Que Lab
Awards
1R01DK132251-01 Cell Fate Regulation in Esophageal Progenitor Cells (04/01/22 – 03/31/26) PI: Que, Jianwen, MPI: Lu, Chao

1P30DK132710-01 (Enrichment Program) (04/30/22 – 03/31/23) Scope – PI: Schwabe, Robert, Co-director of Enrichment Program

1R01CA272901-01 (09/01/22 – 08/31/23) Scope – PI: Wang, Timothy, MPI: Que, Jianwen

P01CA268991 (NCI) 07/01/2022 – 06/30/2027 lead PI: Wael El-Rifai, Project 3: Que, Jianwen (PI)

Publications
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L.Adv Sci (Weinh). 2022 Nov 17:e2204190. doi: 10.1002/advs.202204190. Online ahead of print.PMID: 36394167

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Mol Cell. 2022 Sep 29:S1097-2765(22)00896-6. doi: 10.1016/j.molcel.2022.09.007. Online ahead of print. PMID: 36206767

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling.
Li TW, Kenney AD, Park JG, Fiches GN, Liu H, Zhou D, Biswas A, Zhao W, Que J, Santoso N, Martinez-Sobrido L, Yount JS, Zhu J.Front Immunol. 2022 Sep 13;13:1007089. doi: 10.3389/fimmu.2022.1007089. eCollection 2022. PMID: 36177032

Contribution of Trp63CreERT2 labeled cells to alveolar regeneration is independent of tuft cells.
Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J.Elife. 2022 Sep 21;11:e78217. doi: 10.7554/eLife.78217. Online ahead of print. PMID: 36129169

Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.
Wei X, Zhang L, Zhang Y, Cooper C, Brewer C, Tsai CF, Wang YT, Glaz M, Wessells HB, Que J, Titus MA, Cirulli V, Glaser A, Liu T, Reder NP, Creighton CJ, Xin L.Cell Rep. 2022 Sep 6;40(10):111313. doi: 10.1016/j.celrep.2022.111313. PMID: 36070687

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas.
Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, Wang TC, Giordano S, Zaika A, McDonald O, Peng D, El-Rifai W.J Exp Clin Cancer Res. 2022 Sep 1;41(1):264. doi: 10.1186/s13046-022-02472-5.PMID: 36045416

Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis.
Palrasu M, Zaika E, Paulrasu K, Caspa Gokulan R, Suarez G, Que J, El-Rifai W, Peek RM Jr, Garcia-Buitrago M, Zaika AI.PLoS Pathog. 2022 Jun 29;18(6):e1010628. doi: 10.1371/journal.ppat.1010628. eCollection 2022 Jun. PMID: 35767594

Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma.
Chen L, Lu H, Peng D, Cao LL, Ballout F, Srirmajayam K, Chen Z, Bhat A, Wang TC, Capobianco A, Que J, McDonald OG, Zaika A, Zhang S, El-Rifai W.Gut. 2022 Jun 24:gutjnl-2022-327076. doi: 10.1136/gutjnl-2022-327076. Online ahead of print. PMID: 35750470

Targeting the SOX2/PARP1 complex to intervene in the growth of esophageal squamous cell carcinoma.
Wang Z, Wang J, Zhao H, Zhao T, Chen Y, Jiang M, Zhang S, Wei Y, Zhang J, Zhou Y, Shi S, Fu Z, Yang Y, Zhang Y, Yang L, Que J, Liu K.Biomed Pharmacother. 2022 Sep;153:113309. doi: 10.1016/j.biopha.2022.113309. Epub 2022 Jun 20. PMID: 35738180

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO.Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202012119. doi: 10.1073/pnas.2202012119. Epub 2022 May 19. PMID: 35588457

Snoeck Lab
Awards and Honors
Dr. Hans-Willem Snoeck has been honored by the Department of Medicine with the Byron M. Thomashow Professor of Medicine (in Microbiology & Immunology) endowed chair.

Grants
Dr. Hans-Willem Snoeck Office of the NIH Director: 1S10OD032447-01
Leica Stellaris 8 Confocal Microscope 06/01/2022-05/31/2023

2R01HL135039-05 Mitochondrial Regulation of Hematopoietic Stem Cells (01/17/22 – 12/31/25) Competitive Renewal

Wang Lab
Dr. Xin Huang has been promoted to Instructor in Medical Sciences, Department of Medicine, Columbia University Irving Medical Center

Awards
Huang, Xin 1R21HD106263-01A1 NICHD – SINE-Mediated Regulation of mRNA Epithranscriptome for Pluripotency Maintenance & Differentiation
07/05/2022 – 06/30/2024

Publications
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity.
Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H, Wang J.Nucleic Acids Res. 2022 Nov 23:gkac1084. doi: 10.1093/nar/gkac1084. Online ahead of print. PMID: 36416264

A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer.
Kim M, Singh M, Lee BK, Hibbs M, Richardson K, Ellies L, Wintle L, Stuart LM, Wang JY, Voon DC, Blancafort P, Wang J, Kim J, Leedman PJ, Woo AJ.Oncogenesis. 2022 Oct 7;11(1):60. doi: 10.1038/s41389-022-00435-1. PMID: 36207293 

ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung.
Nobre AR, Dalla E, Yang J, Huang X, Wullkopf L, Risson E, Razghandi P, Anton ML, Zheng W, Seoane JA, Curtis C, Kenigsberg E, Wang J, Aguirre-Ghiso JA.Nat Cancer. 2022 Sep 1. doi: 10.1038/s43018-022-00424-8. Online ahead of print.PMID: 36050483

Comparative functional genomics identifies unique molecular features of EPSCs.
Malik V, Zang R, Fuentes-Iglesias A, Huang X, Li D, Fidalgo M, Zhou H, Wang J.Life Sci Alliance. 2022 Aug 12;5(11):e202201608. doi: 10.26508/lsa.202201608. Print 2022 Nov.PMID: 35961778

NAC1 modulates autoimmunity by suppressing regulatory T cell-mediated tolerance.
Yang JM, Ren Y, Kumar A, Xiong X, Das JK, Peng HY, Wang L, Ren X, Zhang Y, Ji C, Cheng Y, Zhang L, Alaniz RC, de Figueiredo P, Fang D, Zhou H, Liu X, Wang J, Song J.Sci Adv. 2022 Jul;8(26):eabo0183. doi: 10.1126/sciadv.abo0183. Epub 2022 Jun 29. PMID: 35767626

A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency.
Huang X, Bashkenova N, Hong Y, Lyu C, Guallar D, Hu Z, Malik V, Li D, Wang H, Shen X, Zhou H, Wang J.Cell Rep. 2022 Jun 7;39(10):110928. doi: 10.1016/j.celrep.2022.110928. PMID: 35675764

Pursuing totipotency: authentic totipotent stem cells in culture.
Malik V, Wang J.Trends Genet. 2022 Jul;38(7):632-636. doi: 10.1016/j.tig.2022.03.012. Epub 2022 Apr 18. PMID: 35443932

eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency.
Li D, Yang J, Huang X, Zhou H, Wang J.Sci Adv. 2022 Apr;8(13):eabm0478. doi: 10.1126/sciadv.abm0478. Epub 2022 Mar 30. PMID: 35353581 

Yan Lab
Honors/Awards:
Dr. Kelley Yan
AHA 923718 Anne Taylor 03/14/22 – 09/30/22
Young Investigator Award in Basic Science, AGA
David Y. Graham and Jim T. Schwartz Lectureship, Baylor College of Medicine
Harold and Golden Lamport Award for Excellence in Clinical Science Research, Columbia University commencement award
Future Leaders Program, AGA

Grants:
VP&S Promising Clinician Scientist Award
         Doris Duke Foundation COVID-19 Fund to Retain Clinician-Scientists
         American Heart Association Grant #923718
         Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center
         Role: PI
Precision Medicine Pilot Award
         Central memory T cells in the human colorectal cancer immune microenvironment
         Herbert Irving Comprehensive Cancer Center, Columbia University
         Role: PI (co-PI is Arnold Han)

Publications:
R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development.
Hein RFC, Wu JH, Holloway EM, Frum T, Conchola AS, Tsai YH, Wu A, Fine AS, Miller AJ, Szenker-Ravi E, Yan KS, Kuo CJ, Glass I, Reversade B, Spence JR.Dev Cell. 2022 Jul 11;57(13):1598-1614.e8. doi: 10.1016/j.devcel.2022.05.010. Epub 2022 Jun 8. PMID: 35679862

Presentation of the Julius M. Friedenwald Medal to Timothy C. Wang, MD, AGAF.
Abrams J, Camilleri M, Merchant J, Rustgi AK, Yan K. Gastroenterology. 2022 Jun;162(7):2086-2091. doi: 10.1053/j.gastro.2022.03.021. Epub 2022 Apr 17. PMID: 35443933

Zhao Lab
Awards
Dr. Shang-Hsin (Jason) Wu’s abstract entitled “A CRISPR screen in biliatresone-treated human cholangiocytes identified HMMR as a modulator of biliary injury” was awarded Best in AASLD Liver Meeting”.

Winter - Spring

Awards